It seems like a Great Dane will be the best fit for me as far as temperment/exercise needs/doing well inside/alone(while at work etc). I like big dogs but I'm concerned a Dane might just be TOO big. I live alone in a fairly small home (about 1000sf) and might move into an apartment within the next few years. Would a Great Dane be comfortable/happy in that space? Will it knock the house over?

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As long as you have a place for the dog to roam outside and you exercise the dog regularly they will be fine. Yes they will knock the house over...they are not graceful. My boys tail will clear a table.

As long as you set aside time for exercise and play, a Dane will be happy wherever you are. They are mostly couch potatoes, anyway.